Tg3647 mice over-express human TNF that leads to the gradual development of spontaneous slow progressing chronic inflammatory polyarthritis with 100% penetrance.
Targeting TNF-α as a treatment modality has shown tremendous success, however there are several limitations associated with the current anti-TNF-α biologic drugs including: immunogenicity, life-threatening infections, resistance to treatment, complexity of manufacture and cost of treatment. Ubah et al. report the in vivo efficacy of novel anti-TNF-α formats generated from molecular engineering of variable new antigen receptors (VNARs), originally derived from the immune system of an immunized nurse shark.
Published in Frontiers in Immunology 2019 Mar 22;10:526. doi: 10.3389/fimmu.2019.00526.
Collagen antibody-induced arthritis (CAIA) is a simple mouse model of rheumatoid arthritis that can be used to address questions relating to the pathogenic mechanisms of the disease and serves as a platform for the evaluation of candidate therapeutic agents.
Biomedcode has standardized the model in
- C57BL/6 wild type mice,
- Mice humanized for hTNFR1
- Tg1278TNFKO human TNF transgenic mice
- Mice humanized for both TNF and TNFR1
and developed platforms to allow the evaluation of different arthritis therapeutics.
The evolution of preclinical testing through novel humanized precision disease models