TgA86 a mouse model of human spondyloarthritis

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27
May
2019
Date May 27, 2019
Categories White papers

TgA86 a mouse model of human spondyloarthritis

TgA86 mice overexpress mouse transmembrane TNF from a Δ1-12 mTNF-globin transgene. They develop with 100% incidence peripheral and axial joint pathology accompanied by new bone formation features, all characteristic of human SpA pathology.

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Effect of late treatment on the progression of joint (arthritis) and axial (tail) pathology

 

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  • The disease model
  • Study design
  • Routes of administration
  • Validation data
  • Readouts
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