CAIA: an induced arthritis model for the efficacy evaluation of arthritis therapeutics

BiomedcodeBiomedcode / White papers / CAIA: an induced arthritis model for the efficacy evaluation of arthritis therapeutics
16
Jan
2020
Date January 16, 2020
Categories White papers

CAIA: an induced arthritis model for the efficacy evaluation of arthritis therapeutics

Collagen antibody-induced arthritis (CAIA) is a simple mouse model of rheumatoid arthritis that can be used to address questions relating to the pathogenic mechanisms of the disease and serves as a platform for the evaluation of candidate therapeutic agents.

Biomedcode has standardized the model in

  1. C57BL/6 wild type mice,
  2. Mice humanized for hTNFR1
  3. Tg1278TNFKO human TNF transgenic mice
  4. Mice humanized for both TNF and TNFR1

and developed platforms to allow the evaluation of different arthritis therapeutics.

Representative CAIA in-vivo arthritis progression in Tg1278TNFKO animals treated prophylactically with anti-hTNF therapeutics.

 

 

Download the whitepaper to learn more on:

  • The disease model
  • Study design
  • Routes of administration
  • Validation data
  • Readouts
  • Analysis options

DOWNLOAD PDF

Author biomeduser

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