IL-23

BiomedcodeBiomedcode / HUMANIZED TARGETS / IL-23

IL-23 as a therapeutic target

The Interleukin 23 (IL-23) cytokine is a heterodimeric cytokine consisting of the two subunits p19 and p40. It is an inducer of the Th17 cell population and a component of the IL-23/IL-17 immune pathway which is an orchestrator of many pathological conditions, including psoriasis. 

Due to its crucial role in pathogenesis, the two IL-23 subunits are promising therapeutic targets for inflammatory conditions. The first approved biologic agent targeting IL-23 was ustekinumab (Stelara), a fully human monoclonal antibody against the shared IL-12/IL23 p40 subunit that was approved for the indication of psoriasis and Chron’s disease. Guselkumab (Tremfya), a monoclonal antibody targeting the IL23p19 subunit was recently approved for the treatment of psoriasis, while tildrakizumab (Ilumya), also targeting IL23p19, and other therapeutics are currently under development.

The humanised IL23 mouse models

We have developed and characterized transgenic mice expressing in a dysregulated manner either the human IL23p19 (TghIL23p19) or the human IL12p40 (TgK14hIL12p40).  In both transgenic lines, dysregulation is the result of the replacement of the gene’s 3’UTR with that of beta globin that is not subject to posttranscriptional regulation. Expression pattern is determined by the promoters used, that is the gene’s  own promoter for TghIL23p19 and the human keratin 14 promoter for TghIl12p40. Both transgenic lines develop lupus-like autoimmune pathologies and are available for testing therapeutics.

Model Disease Treatment Pathology Read outs
TghIL23p19 Lupus-like Guselkumab -Dermatits
-Splenomegaly
-Renal pathology		 -Weight
-Skin clinical scoring
-Histology
-Circulating IgG levels
-Urine protein
TgK14hIL12p40 Lupus-like Ustekinumab -Dermatits
-Splenomegaly
-Renal pathology		 -Weight
-Skin clinical scoring
-Histology
-Circulating IgG levels
-Urine protein

RELATED PROJECTS

Privacy settings

Decide which cookies you want to allow. You can change these settings at any time. However, this can result in some functions no longer being available. For information on deleting the cookies, please consult your browser’s help function. Learn more about the cookies we use.

With the slider, you can enable or disable different types of cookies:

This website will:

  • Essential: Remember your cookie permission setting
  • Essential: Allow session cookies
  • Essential: Gather information you input into a contact forms, newsletter and other forms across all pages
  • Essential: Keep track of what you input in a shopping cart
  • Essential: Authenticate that you are logged into your user account
  • Essential: Remember language version you selected

This website won't:

  • Remember your login details
  • Functionality: Remember social media settings
  • Functionality: Remember selected region and country
  • Analytics: Keep track of your visited pages and interaction taken
  • Analytics: Keep track about your location and region based on your IP number
  • Analytics: Keep track of the time spent on each page
  • Analytics: Increase the data quality of the statistics functions
  • Advertising: Tailor information and advertising to your interests based on e.g. the content you have visited before. (Currently we do not use targeting or targeting cookies.
  • Advertising: Gather personally identifiable information such as name and location

This website will:

  • Essential: Remember your cookie permission setting
  • Essential: Allow session cookies
  • Essential: Gather information you input into a contact forms, newsletter and other forms across all pages
  • Essential: Keep track of what you input in a shopping cart
  • Essential: Authenticate that you are logged into your user account
  • Essential: Remember language version you selected
  • Functionality: Remember social media settings
  • Functionality: Remember selected region and country

This website won't:

  • Remember your login details
  • Analytics: Keep track of your visited pages and interaction taken
  • Analytics: Keep track about your location and region based on your IP number
  • Analytics: Keep track of the time spent on each page
  • Analytics: Increase the data quality of the statistics functions
  • Advertising: Tailor information and advertising to your interests based on e.g. the content you have visited before. (Currently we do not use targeting or targeting cookies.
  • Advertising: Gather personally identifiable information such as name and location

This website will:

  • Essential: Remember your cookie permission setting
  • Essential: Allow session cookies
  • Essential: Gather information you input into a contact forms, newsletter and other forms across all pages
  • Essential: Keep track of what you input in a shopping cart
  • Essential: Authenticate that you are logged into your user account
  • Essential: Remember language version you selected
  • Functionality: Remember social media settingsl Functionality: Remember selected region and country
  • Analytics: Keep track of your visited pages and interaction taken
  • Analytics: Keep track about your location and region based on your IP number
  • Analytics: Keep track of the time spent on each page
  • Analytics: Increase the data quality of the statistics functions

This website won't:

  • Remember your login details
  • Advertising: Use information for tailored advertising with third parties
  • Advertising: Allow you to connect to social sites
  • Advertising: Identify device you are using
  • Advertising: Gather personally identifiable information such as name and location

This website will:

  • Essential: Remember your cookie permission setting
  • Essential: Allow session cookies
  • Essential: Gather information you input into a contact forms, newsletter and other forms across all pages
  • Essential: Keep track of what you input in a shopping cart
  • Essential: Authenticate that you are logged into your user account
  • Essential: Remember language version you selected
  • Functionality: Remember social media settingsl Functionality: Remember selected region and country
  • Analytics: Keep track of your visited pages and interaction taken
  • Analytics: Keep track about your location and region based on your IP number
  • Analytics: Keep track of the time spent on each page
  • Analytics: Increase the data quality of the statistics functions
  • Advertising: Use information for tailored advertising with third parties
  • Advertising: Allow you to connect to social sitesl Advertising: Identify device you are using
  • Advertising: Gather personally identifiable information such as name and location

This website won't:

  • Remember your login details
Save & Close