The TNFΔARE Preclinical Platform for the preclinical testing of therapeutics targeting rheumatoid arthritis and intestinal inflammation

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17
Apr
2019
Date April 17, 2019
Categories White papers

The TNFΔARE Preclinical Platform for the preclinical testing of therapeutics targeting rheumatoid arthritis and intestinal inflammation

The TNFΔARE mouse model develops arthritis pathology together with Crohn’s like ileal inflammation with 100% penetrance. The co-occurence of two inflammatory pathologies provide a reliable in-vivo model for evaluating therapeutics targeting both pathologies.

Grip strength force modulation with age in wt and TNFΔARE mice treated or not with Enbrel 

 

Download the whitepaper to learn more on:

  • The disease model
  • Study design
  • Routes of administration
  • Validation data
  • Readouts
  • Analysis options

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